Members of the Clapham Sect included:
- Thomas Fowell Buxton (1786–1845), MP and brewer
- William Dealtry (1775–1847), Rector of Clapham, mathematician
- Edward James Eliot (1758–97), parliamentarian
- Thomas Gisbourne (1758–1846), clergyman and author
- Charles Grant (1746–1823), administrator, chairman of the directors of the British East India Company, father of the first Lord Glenelg
- Katherine Hankey (1834–1911), evangelist
- Zachary Macaulay (1768–1838), estate manager, colonial governor, father of Thomas Babington Macaulay
- Hannah More (1745–1835), writer and philanthropist
- Granville Sharp (1735–1813), scholar and administrator
- Charles Simeon (1759–1836), Anglican minister, promoter of missions
- James Stephen (1758–1832), Master of Chancery, great-grandfather of Virginia Woolf.
- Lord Teignmouth (1751–1834), Governor-General of India
- Henry Thornton (1760–1815), economist, banker, philanthropist, MP for Southwark, great-grandfather of writer E.M. Forster
- Henry Venn (1725–97), founder of the group, father of John Venn and great-grandfather of John Venn (originator of the Venn diagram)
- John Venn (1759–1813), Rector of Holy Trinity Church, Clapham
- William Wilberforce (1759–1833), MP successively for Kingston upon Hull, Yorkshire and Bramber, leading abolitionist. He was also a Wesleyan and it was to Wilberforce that John Wesley wrote his last letter.